Fluoxetine updated on 07-01-2025

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7469
R22202		 Anderson, 2020 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.55 [0.56;4.27] -/-   0/- - -
ref
S7349
R21470		 Wemakor, 2015 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 4.39 [1.04;18.54] C 2/29   288/17,344 290 29
ref
Total 2 studies 2.29 [0.85;6.14] 290 29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.55[0.56; 4.27]--63%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 4.39[1.04; 18.54]2902937%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 25% 2.29[0.85; 6.14]290290.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.29[0.85; 6.14]2902925%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.29[0.85; 6.14]2902925%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - No  - No 4.39[1.04; 18.54]29029 -NAWemakor, 2015 1   - Yes  - Yes 1.55[0.56; 4.28]-- -NAAnderson, 2020 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.29[0.85; 6.14]2902925%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 2.29[0.85; 6.14]2902925%NAAnderson, 2020 Wemakor, 2015 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.29[0.85; 6.14]2902925%NAAnderson, 2020 Wemakor, 2015 20.510.01.0