Fluoxetine updated on 07-01-2025

Club foot / Talipes equinovarus

id	Study   Auto Furu, 2015Wemakor, 2015Yazdy, 2014Louik, 2007	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S6004 R15374	Furu, 2015	Clubfoot	1st trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.08 [0.58;2.02]	12/6,250   3,174/2,266,875	3,186	6,250		ref
S7349 R21452	Wemakor, 2015	Club foot	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.65 [0.68;4.03]	6/33   1,986/19,042	1,992	33		ref
S7904 R23941	Yazdy, 2014	Club foot	1st trimester	case control	unexposed, disease free	Adjustment: Yes Monotherapy: no or not specified	1.30 [0.40;4.20]	4/15   618/2,609	622	15		ref
S6157 R16124	Louik, 2007	Clubfoot	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...)	0.80 [0.20;2.50]	3/64   410/6,209	413	64		ref
					Total	4 studies	1.19 [0.76;1.84]		6,213	6,362
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)