Mebendazole updated on 01-29-2025

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17569
R74076		 Torp-Pedersen (Controls exposed to Pyrviniumn), 2016 Stillbirth (> 22 or 28 completed weeks) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.87 [0.27;2.73] C
excluded (control group) 		7/2,567   5/1,588 12 2,567
ref
S17570
R74082		 Torp-Pedersen (Controls unexposed, NOS), 2016 Stillbirth (> 22 or 28 completed weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.90 [0.40;2.10] 7/2,567   2,548/708,982 2,555 2,567
ref
Total 1 studies 0.90 [0.39;2.06] 2,555 2,567
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Torp-Pedersen (Controls unexposed, NOS), 2016Torp-Pedersen, 2016 1 0.90[0.40; 2.10]2,5552,5670%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.39; 2.06]2,5552,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.39; 2.06]2,5552,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 Tags Adjustment   - Yes  - Yes 0.90[0.39; 2.06]2,5552,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 All studiesAll studies 0.90[0.39; 2.06]2,5552,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17569

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.39; 2.06]2,5552,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.87[0.27; 2.73]122,567 -NATorp-Pedersen (Controls exposed to Pyrviniumn), 2016 10.510.01.0