Mebendazole updated on 01-29-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17571
R74088		 Acs, 2005 Cardiovascular congenital abnormalities 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Matched 5.10 [0.40;58.40] 1/3   4,478/42,627 4,479 3
ref
S17567
R74062		 De Silva, 1999 Cardiovascular system during pregnancy (anytime or not specified) excluded retrospective cohort unexposed (general population or NOS) Adjustment: No 0.88 [0.21;4.18]
excluded (exposition period) 		8/5,275   3/1,737 11 5,275
ref
Total 1 studies 5.10 [0.42;61.62] 4,479 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Acs, 2005Acs, 2005 5.10[0.40; 58.40]4,47930%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 5.10[0.42; 61.62]4,4793 -NAAcs, 2005 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.10[0.42; 61.62]4,4793 -NAAcs, 2005 1 Tags Adjustment   - Yes  - Yes 5.10[0.42; 61.62]4,4793 -NAAcs, 2005 1 MatchedMatched 5.10[0.42; 61.62]4,4793 -NAAcs, 2005 1 All studiesAll studies 5.10[0.42; 61.62]4,4793 -NAAcs, 2005 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.10[0.42; 61.62]4,4793 -NAAcs, 2005 10.510.01.0