Mebendazole updated on 01-29-2025

Minor congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17569
R74075		 Torp-Pedersen (Controls exposed to Pyrviniumn), 2016 Minor congenital malformations 1st trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.52 [0.22;1.21] C
excluded (control group) 		12/1,022   10/445 22 1,022
ref
S17570
R74081		 Torp-Pedersen (Controls unexposed, NOS), 2016 Minor congenital malformations 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.80 [0.50;1.40] 12/1,022   13,629/708,982 13,641 1,022
ref
Total 1 studies 0.80 [0.48;1.34] 13,641 1,022
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Torp-Pedersen (Controls unexposed, NOS), 2016Torp-Pedersen, 2016 1 0.80[0.50; 1.40]13,6411,0220%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.48; 1.34]13,6411,022 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.48; 1.34]13,6411,022 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 Tags Adjustment   - Yes  - Yes 0.80[0.48; 1.34]13,6411,022 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 All studiesAll studies 0.80[0.48; 1.34]13,6411,022 -NATorp-Pedersen (Controls unexposed, NOS), 2016 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17569

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.48; 1.34]13,6411,022 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.52[0.22; 1.21]221,022 -NATorp-Pedersen (Controls exposed to Pyrviniumn), 2016 10.510.01.0