Mebendazole updated on 01-29-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17569
R74077		 Torp-Pedersen (Controls exposed to Pyrviniumn), 2016 Neonatal mortality (death within 28 full days of life) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.62 [0.18;2.14] C
excluded (control group) 		5/2,567   5/1,588 10 2,567
ref
S17570
R74083		 Torp-Pedersen (Controls unexposed, NOS), 2016 Neonatal mortality (death within 28 full days of life) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes 0.80 [0.30;2.20] 5/2,567   2,055/708,982 2,060 2,567
ref
Total 1 studies 0.80 [0.30;2.17] 2,060 2,567
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Torp-Pedersen (Controls unexposed, NOS), 2016Torp-Pedersen, 2016 1 0.80[0.30; 2.20]2,0602,5670%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.30; 2.17]2,0602,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.30; 2.17]2,0602,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 Tags Adjustment   - Yes  - Yes 0.80[0.30; 2.17]2,0602,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 All studiesAll studies 0.80[0.30; 2.17]2,0602,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17569

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.30; 2.17]2,0602,567 -NATorp-Pedersen (Controls unexposed, NOS), 2016 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.62[0.18; 2.14]102,567 -NATorp-Pedersen (Controls exposed to Pyrviniumn), 2016 10.510.01.0