Mebendazole updated on 01-29-2025

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17571
R74087		 Acs, 2005 Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Matched 8.60 [0.80;95.30] 1/3   3,037/41,186 3,038 3
ref
Total 1 studies 8.60 [0.79;93.86] 3,038 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Acs, 2005Acs, 2005 8.60[0.80; 95.30]3,03830%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 8.60[0.79; 93.86]3,0383 -NAAcs, 2005 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 8.60[0.79; 93.86]3,0383 -NAAcs, 2005 1 Tags Adjustment   - Yes  - Yes 8.60[0.79; 93.86]3,0383 -NAAcs, 2005 1 MatchedMatched 8.60[0.79; 93.86]3,0383 -NAAcs, 2005 1 All studiesAll studies 8.60[0.79; 93.86]3,0383 -NAAcs, 2005 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.60[0.79; 93.86]3,0383 -NAAcs, 2005 10.510.01.0