Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

Cognitive developmental disorders/delay (3-6 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16328
R67819		 Liew a, 2016 Full-scale IQ - Wechsler Primary and Preschool Scales of intelligence-revised (WPPSi-r) - 5 years old during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy 1.16 [0.96;1.40] -/881   -/610 - 881
ref
Total 1 studies 1.16 [0.96;1.40] 0 881
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Liew a, 2016Liew a, 2016 1.16[0.96; 1.40]-8810%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.16[0.96; 1.40]-881 -NALiew a, 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.16[0.96; 1.40]-881 -NALiew a, 2016 1 Tags Adjustment   - Yes  - Yes 1.16[0.96; 1.40]-881 -NALiew a, 2016 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.16[0.96; 1.40]-881 -NALiew a, 2016 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.16[0.96; 1.40]-881 -NALiew a, 2016 1 All studiesAll studies 1.16[0.96; 1.40]-881 -NALiew a, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.16[0.96; 1.40]-881 -NALiew a, 2016 10.510.01.0