Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

ASD (Autism spectrum disorder): Diagnosis/Risk

id	Study   Auto Ahlqvist (Population-Based), 2024Ahlqvist (Sibling), 2024Liew b, 2016	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S16219 R67858	Ahlqvist (Population-Based), 2024	Autism - ICD-10 (F84) or ICD-9 (299) - Median (IQR) follow-up of 13.4 (7.6-19.8) years	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.05 [1.02;1.08]	5,912/185,909   62,672/2,294,888	68,584	185,909		ref
S16218 R67859	Ahlqvist (Sibling), 2024	Autism - ICD-10 (F84) or ICD-9 (299) - Median (IQR) follow-up of 13.4 (7.6-19.8) years	during pregnancy (anytime or not specified)	population based cohort retrospective	sibling excluded	Adjustment: Yes Control group: Sibling Paracetamol use: maternal ITW/questionnaires during pregnancy	0.98 [0.93;1.04] excluded (control group)	3,956/-   41,294/-	45,250	-		ref
S16316 R67860	Liew b, 2016	Autism Spectrum Disorder diagnosis (ICD-10 F84.0-F84.9) - Follow-up 11-17 years old (average 12.7 years)	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.19 [1.04;1.35]	626/36,187   401/28,135	1,027	36,187		ref
					Total	2 studies	1.10 [0.98;1.24]		69,611	222,096
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 16218

Umbrella review (other published meta-analyses)