Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

Psychomotor developmental disorders/delay

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16410
R67743		 Bertoldi_Pelotas, 2020 Cognitive development (Motor) - INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) - Mean (SD) 2.0 (0.06) years (Acetaminophen 1st, 2nd, or 3rd trim) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy 0.93 [0.82;1.05] -/2,470   -/1,348 - 2,470
ref
S16321
R67441		 Tovo-Rodrigues, 2020 Motor area (< 10th percentile) - Battelle's Developmental Inventory - At 24 months during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy 0.91 [0.71;1.16] -/-   -/- - -
ref
S16322
R67568		 Vlenterie, 2016 Motor milestone problems - Age at which the child started walking unaided - At 18 months of age (< 28 days of paracetamol use) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Matched Paracetamol use: maternal ITW/questionnaires during pregnancy 1.06 [0.98;1.15] 1,328/13,503   1,258/13,503 2,586 13,503
ref
Total 3 studies 0.99 [0.89;1.10] 2,586 15,973
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bertoldi_Pelotas, 2020Bertoldi_Pelotas, 2020 0.93[0.82; 1.05]-2,47036%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Tovo-Rodrigues, 2020Tovo-Rodrigues, 2020 0.91[0.71; 1.16]--14%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Vlenterie, 2016Vlenterie, 2016 1.06[0.98; 1.15]2,58613,50350%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 47% 0.99[0.89; 1.10]2,58615,9730.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.99[0.89; 1.10]2,58615,97347%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 Vlenterie, 2016 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.99[0.89; 1.10]2,58615,97347%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 Vlenterie, 2016 3 Tags Adjustment   - No  - No 0.93[0.82; 1.05]-2,470 -NABertoldi_Pelotas, 2020 1   - Yes  - Yes 1.03[0.91; 1.16]2,58613,50325%NATovo-Rodrigues, 2020 Vlenterie, 2016 2 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.93[0.82; 1.05]-2,470 -NABertoldi_Pelotas, 2020 1 MatchedMatched 1.06[0.98; 1.15]2,58613,503 -NAVlenterie, 2016 1 Paracetamol use   - maternal ITW/questionnaires after p ...  - maternal ITW/questionnaires after pregnancy 0.91[0.71; 1.16]-- -NATovo-Rodrigues, 2020 1   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.00[0.88; 1.14]2,58615,97367%NABertoldi_Pelotas, 2020 Vlenterie, 2016 2 All studiesAll studies 0.99[0.89; 1.10]2,58615,97347%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 Vlenterie, 2016 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.99[0.89; 1.10]2,58615,97347%NABertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 Vlenterie, 2016 30.510.01.0