| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S16286 R67289 |
Woodbury a, 2024 | Expressive vocabulary score (≤25th percentile) - MacArthur-Bates Communicative Development Inventories (CDI) Parent's report - Average age of 27.42 (±1.08) months | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.00 [0.99;1.01] | -/208 -/90 | - | 208 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16410 R67742 |
Bertoldi_Pelotas, 2020 | Cognitive development (Language) - INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) - Mean (SD) 2.0 (0.06) years (Acetaminophen 1st, 2nd, or 3rd trim) | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: No extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.00 [0.89;1.13] | -/2,470 -/1,348 | - | 2,470 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16321 R67442 |
Tovo-Rodrigues, 2020 | Communication area (< 10th percentile) - Battelle's Developmental Inventory - At 24 months | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires after pregnancy | 1.04 [0.84;1.30] | -/- -/- | - | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16333 R67538 |
Tronnes, 2020 | Communication problems (T scores ≥65) - The Ages and Stages Questionnaire (ASQ), Parents completed - At 5 years (use in one trimester) | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy | 0.98 [0.88;1.09] | 605/8,180 1,281/17,317 | 1,886 | 8,180 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S16328 R67820 |
Liew a, 2016 | Verbal IQ - Wechsler Primary and Preschool Scales of intelligence-revised (WPPSi-r) - 5 years old | during pregnancy (anytime or not specified) | prospective cohort | unexposed (general population or NOS) | Adjustment: Yes extrapolated (cont. endpoint) Paracetamol use: maternal ITW/questionnaires during pregnancy | 1.08 [0.90;1.31] | -/881 -/610 | - | 881 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 5 studies | 1.00 [0.99;1.01] | 1,886 | 11,739 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Asymetry test p-value = 0.5632 (by Egger's regression)
slope=0.0019 (0.0031); intercept=0.1787 (0.2757); t=0.6479; p=0.5632
excluded