Acetaminophen (Neuro-developmental outcomes) - Medication and Pregnancy KB

Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

Severe cognitive developmental delay (Mental retardation) (> 6 years old)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S16219 R67164	Ahlqvist (Population-Based), 2024	Intellectual disability - ICD-10 (F70-F79) or ICD-9 (317-319) - Median (IQR) follow-up of 13.4 (7.6-19.8) years (median diag 8.2 (5.3- 12.7))	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.05 [1.00;1.10]	2,084/185,909 22,470/2,294,888	24,554	185,909		ref
S16218 R67161	Ahlqvist (Sibling), 2024	Intellectual disability - ICD-10 (F70-F79) or ICD-9 (317-319) - Median (IQR) follow-up of 13.4 (7.6-19.8) years (median diag 8.2 (5.3- 12.7))	during pregnancy (anytime or not specified)	population based cohort retrospective	sibling excluded	Adjustment: Yes Control group: Sibling Paracetamol use: maternal ITW/questionnaires during pregnancy	1.01 [0.92;1.10] excluded (control group)	1,350/- 14,009/-	15,359	-		ref
					Total	1 studies	1.05 [1.00;1.10]		24,554	185,909
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Population-Based;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 16218