Acetaminophen (Neuro-developmental outcomes) - Medication and Pregnancy KB

Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

ADHD (Attention deficit hyperactivity disorder): Diagnosis

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S16219 R67163	Ahlqvist (Population-Based), 2024	Attention-deficit/hyperactivity disorder (ADHD) - ICD-10 (F90) or ICD-9 (314) - Median (IQR) follow-up of 13.4 (7.6-19.8) years	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.07 [1.05;1.10]	12,834/185,909 133,552/2,294,888	146,386	185,909		ref
S16218 R67160	Ahlqvist (Sibling), 2024	Attention-deficit/hyperactivity disorder (ADHD) - ICD-10 (F90) or ICD-9 (314) - Median (IQR) follow-up of 13.4 (7.6-19.8) years	during pregnancy (anytime or not specified)	population based cohort retrospective	sibling excluded	Adjustment: Yes Control group: Sibling Paracetamol use: maternal ITW/questionnaires during pregnancy	0.98 [0.94;1.02] excluded (control group)	8,526/- 87,679/-	96,205	-		ref
S16220 R67165	Chen, 2019	Diagnoses of ADHD (ICD-9-CM code: 314) by board-certified psychiatrists on the basis of diagnostic interviews and clinical judgement - Age 0 - 15 years old (mean diagnosis 3.71)	during pregnancy (anytime or not specified)	nested case control	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: prescription or medical files	1.20 [1.01;1.42]	676/3,236 274/1,514	950	3,236		ref
S16253 R67195	Ystrom or Gustavson (Gustavson 2021 - Sibling), 2017	Attention deficit hyperactivity disorder - ICD-10 code F90 - Between 0 and 18 years old (Exposed 1–7 days)	during pregnancy (anytime or not specified)	prospective cohort	sibling excluded	Adjustment: Yes Control group: Sibling Paracetamol use: maternal ITW/questionnaires during pregnancy	0.87 [0.70;1.08] excluded (control group)	-/6,490 -/12,080	-	6,490		ref
S16290 R67298	Ystrom or Gustavson (Ystrom - Population-Based), 2017	Attention-deficit/hyperactivity (ADHD - diagnosis of hyperkinetic disorder (F90.0, F90.1, F90.8, or F90.9)) - At 3-15 years old.	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.12 [1.02;1.24]	-/52,707 -/60,266	-	52,707		ref
S16275 R67240	Liew, 2014	Hyperkinetic disorder diagnosis (ICD-10: F90.0-F90.9) - Mean age of children at the end of follow-up: 10.7 years (range, 8.2-13.4 years)	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy	1.37 [1.19;1.59]	551/36,187 283/28,135	834	36,187		ref
					Total	4 studies	1.16 [1.05;1.29]		148,170	278,039
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Population-Based; 2: Ystrom - Population-Based;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded 16253, 16218