Acetaminophen (Neuro-developmental outcomes) updated on 07-16-2024

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S16316
R67392		 Liew b, 2016 Infantile autism (ICD-10 F84.0) - Follow-up 11-17 years old (average 12.7 years) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes Paracetamol use: maternal ITW/questionnaires during pregnancy 1.10 [0.89;1.37] 206/36,187   139/28,135 345 36,187
ref
Total 1 studies 1.10 [0.89;1.36] 345 36,187
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Liew b, 2016Liew b, 2016 1.10[0.89; 1.37]34536,1870%ROB confusion: moderateROB selection: lowROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.89; 1.36]34536,187 -NALiew b, 2016 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.10[0.89; 1.36]34536,187 -NALiew b, 2016 1 Tags Adjustment   - Yes  - Yes 1.10[0.89; 1.36]34536,187 -NALiew b, 2016 1 Paracetamol use   - maternal ITW/questionnaires during ...  - maternal ITW/questionnaires during pregnancy 1.10[0.89; 1.36]34536,187 -NALiew b, 2016 1 All studiesAll studies 1.10[0.89; 1.36]34536,187 -NALiew b, 2016 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.10[0.89; 1.36]34536,187 -NALiew b, 2016 10.510.01.0