Midazolam - Medication and Pregnancy KB

Midazolam updated on 02-10-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17856 R75347	Meng a (Controls unexposed, sibling), 2023	Stillbirth (fetal death at or after 20 weeks’ gestation)	early pregnancy	population based cohort retrospective	sibling excluded	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	3.18 [1.49;6.78] excluded (control group)	-/- -/-	-	-		ref
S15635 R64528	Meng a (Controls unexposed, sick), 2023	Stillbirth (fetal death at or after 20 weeks’ gestation)	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	2.70 [1.99;3.68]	46/1,317 36,495/2,763,341	36,541	1,317		ref
					Total	1 studies	2.70 [1.99;3.67]		36,541	1,317
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17856