Flunitrazepam updated on 02-10-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17855
R75345		 Meng a (Controls unexposed, sibling), 2023 Preterm birth (<37 weeks’ gestation) early pregnancy population based cohort retrospective sibling excluded Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.14 [0.80;1.61]
excluded (control group) 		-/-   -/- - -
ref
S15634
R64526		 Meng a (Controls unexposed, sick), 2023 Preterm birth (<37 weeks’ gestation) early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.62 [1.44;1.83] 402/2,581   274,708/2,696,349 275,110 2,581
ref
Total 1 studies 1.62 [1.44;1.83] 275,110 2,581
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng a (Controls unexposed, sick), 2023Meng a, 2023 1 1.62[1.44; 1.83]275,1102,5810%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.62[1.44; 1.83]275,1102,581 -NAMeng a (Controls unexposed, sick), 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.62[1.44; 1.83]275,1102,581 -NAMeng a (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 1.62[1.44; 1.83]275,1102,581 -NAMeng a (Controls unexposed, sick), 2023 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.62[1.44; 1.83]275,1102,581 -NAMeng a (Controls unexposed, sick), 2023 1 All studiesAll studies 1.62[1.44; 1.83]275,1102,581 -NAMeng a (Controls unexposed, sick), 2023 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17855

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.62[1.44; 1.83]275,1102,581 -NAMeng a (Controls unexposed, sick), 2023 1 siblingssiblings 1.14[0.80; 1.62]-- -NAMeng a (Controls unexposed, sibling), 2023 10.510.01.0