Clotiazepam updated on 02-10-2025

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15386
R63444		 Noh, 2022 Overall major congenital malformations 1st trimester population based cohort retrospective unexposed, sick Adjustment: Yes BZD Coexposure: Not specified 0.91 [0.75;1.11] 95/1,896   156,896/3,053,381 156,991 1,896
ref
Total 1 studies 0.91 [0.75;1.11] 156,991 1,896
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Noh, 2022Noh, 2022 0.91[0.75; 1.11]156,9911,8960%ROB confusion: moderateROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: low0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.75; 1.11]156,9911,896 -NANoh, 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.91[0.75; 1.11]156,9911,896 -NANoh, 2022 1 Tags Adjustment   - Yes  - Yes 0.91[0.75; 1.11]156,9911,896 -NANoh, 2022 1 BZD Coexposure   - Not specified  - Not specified 0.91[0.75; 1.11]156,9911,896 -NANoh, 2022 1 All studiesAll studies 0.91[0.75; 1.11]156,9911,896 -NANoh, 2022 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.91[0.75; 1.11]156,9911,896 -NANoh, 2022 10.510.01.0