Fludiazepam - Medication and Pregnancy KB

Fludiazepam updated on 02-10-2025

Small for gestational age (weight)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17853 R75340	Meng a (Controls unexposed, sibling), 2023	Small for gestational age (birthweight below the 10th percentile for gestational age by sex)	early pregnancy	population based cohort retrospective	sibling excluded	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.21 [1.00;1.46] excluded (control group)	-/- -/-	-	-		ref
S15632 R64521	Meng a (Controls unexposed, sick), 2023	Small for gestational age (birthweight below the 10th percentile for gestational age by sex)	early pregnancy	population based cohort retrospective	unexposed, sick	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.17 [1.09;1.27]	781/6,939 269,533/2,764,422	270,314	6,939		ref
					Total	1 studies	1.17 [1.08;1.26]		270,314	6,939
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17853