Fludiazepam updated on 02-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15616
R64445		 Meng b, 2023 Miscarriage (between 8th-19th weeks of gestation; ICD-9 codes 631, 632, 634, 637, 640; ICD-10 codes 631, 632, 634, 637, 640) during pregnancy (anytime or not specified) other unexposed, sick Adjustment: Yes BZD Coexposure: Not specified Matched 2.52 [1.89;3.36] -/-   0/- - -
ref
Total 1 studies 2.52 [1.89;3.36] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng b, 2023Meng b, 2023 2.52[1.89; 3.36]--0%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.52[1.89; 3.36]-- -NAMeng b, 2023 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.52[1.89; 3.36]-- -NAMeng b, 2023 1 Tags Adjustment   - Yes  - Yes 2.52[1.89; 3.36]-- -NAMeng b, 2023 1 BZD Coexposure   - Not specified  - Not specified 2.52[1.89; 3.36]-- -NAMeng b, 2023 1 MatchedMatched 2.52[1.89; 3.36]-- -NAMeng b, 2023 1 All studiesAll studies 2.52[1.89; 3.36]-- -NAMeng b, 2023 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.52[1.89; 3.36]-- -NAMeng b, 2023 10.510.01.0