Alprazolam updated on 02-10-2025

Cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17690
R74671		 Laspro, 2024 Isolated Cleft Palate (ICD-10 code Q35 excluding Q36 or Q37) during pregnancy (anytime or not specified) excluded nested case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 1.52 [1.26;1.84]
excluded (exposition period) 		109/-   5,750/- 5,859 -
ref
S15600
R64262		 Tinker, 2019 Cleft palate alone 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.50 [0.70;3.10] 9/47   1,569/13,064 1,578 47
ref
S17862
R75385		 Eros, 2002 Cleft palate during pregnancy (anytime or not specified) excluded case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched no data
excluded (exposition period) 		0/-   -/- - -
ref
Total 1 studies 1.50 [0.71;3.16] 1,578 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 1.50[0.70; 3.10]1,578470%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.50[0.71; 3.16]1,57847 -NATinker, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.50[0.71; 3.16]1,57847 -NATinker, 2019 1 Tags Adjustment   - Yes  - Yes 1.50[0.71; 3.16]1,57847 -NATinker, 2019 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.50[0.71; 3.16]1,57847 -NATinker, 2019 1 All studiesAll studies 1.50[0.71; 3.16]1,57847 -NATinker, 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.50[0.71; 3.16]1,57847 -NATinker, 2019 10.510.01.0