Clobazam (Psy and Mixed indications) updated on 02-10-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15627
R64506		 Kilic (Mixed indications), 2014 Preterm (< 37 weeks) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No BZD Coexposure: No (among antiseizure medications) 3.30 [1.50;3.90] 5/30   33,974/676,834 33,979 30
ref
Total 1 studies 3.30 [2.05;5.32] 33,979 30
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kilic (Mixed indications), 2014Kilic, 2014 1 3.30[1.50; 3.90]33,979300%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.30[2.05; 5.32]33,97930 -NAKilic (Mixed indications), 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.30[2.05; 5.32]33,97930 -NAKilic (Mixed indications), 2014 1 Tags Adjustment   - No  - No 3.30[2.05; 5.32]33,97930 -NAKilic (Mixed indications), 2014 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 3.30[2.05; 5.32]33,97930 -NAKilic (Mixed indications), 2014 1 All studiesAll studies 3.30[2.05; 5.32]33,97930 -NAKilic (Mixed indications), 2014 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.30[2.05; 5.32]33,97930 -NAKilic (Mixed indications), 2014 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Veroniki a (NMA) (Clobazam) (All indications) ...Veroniki a (NMA) (Clobazam) (All indications) (Preterm birth) 3.42[1.41; 7.92]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT-9 metaPregmetaPreg 3.30[2.05; 5.32]NaN%30----Kilic (Mixed indications), 2014 10.510.01.0