Lorazepam updated on 02-10-2025

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17850
R75330		 Meng a (Controls unexposed, sibling), 2023 Preterm birth (<37 weeks’ gestation) early pregnancy population based cohort retrospective sibling excluded Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.17 [1.00;1.34]
excluded (control group) 		-/-   -/- - -
ref
S15629
R64511		 Meng a (Controls unexposed, sick), 2023 Preterm birth (<37 weeks’ gestation) early pregnancy population based cohort retrospective unexposed, sick Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.18 [1.11;1.25] 1,193/11,020   262,028/2,808,117 263,221 11,020
ref
S15321
R63045		 Calderon-Margalit, 2009 Preterm delivery (before 37 weeks of gestation) during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 7.94 [4.47;14.10] 40/73   234/2,493 274 73
ref
Total 2 studies 2.99 [0.46;19.38] 263,495 11,093
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng a (Controls unexposed, sick), 2023Meng a, 2023 1 1.18[1.11; 1.25]263,22111,02051%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Calderon-Margalit, 2009Calderon-Margalit, 2009 7.94[4.47; 14.10]2747349%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 98% 2.99[0.46; 19.38]263,49511,0930.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.99[0.46; 19.38]263,49511,09398%NAMeng a (Controls unexposed, sick), 2023 Calderon-Margalit, 2009 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 7.94[4.47; 14.10]27473 -NACalderon-Margalit, 2009 1 unexposed, sickunexposed, sick 1.18[1.11; 1.25]263,22111,020 -NAMeng a (Controls unexposed, sick), 2023 1 Tags Adjustment   - Yes  - Yes 2.99[0.46; 19.38]263,49511,09398%NAMeng a (Controls unexposed, sick), 2023 Calderon-Margalit, 2009 2 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 2.99[0.46; 19.38]263,49511,09398%NAMeng a (Controls unexposed, sick), 2023 Calderon-Margalit, 2009 2 All studiesAll studies 2.99[0.46; 19.38]263,49511,09398%NAMeng a (Controls unexposed, sick), 2023 Calderon-Margalit, 2009 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17850

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 7.94[4.47; 14.10]27473 -NACalderon-Margalit, 2009 1 unexposed, sick controlsunexposed, sick controls 1.18[1.11; 1.25]263,22111,020 -NAMeng a (Controls unexposed, sick), 2023 1 siblingssiblings 1.17[1.01; 1.35]-- -NAMeng a (Controls unexposed, sibling), 2023 10.510.01.0