Lorazepam updated on 02-10-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15603
R64363		 Tinker, 2019 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 0.72 [0.04;12.64] C 0/7   1,066/12,592 1,066 7
ref
S15654
R64634		 Bonnot, 2003 Anal atresias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified 6.19 [2.44;15.74] 5/-   237/- 242 -
ref
Total 2 studies 3.29 [0.48;22.44] 1,308 7
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 0.72[0.04; 12.64]1,066729%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Bonnot, 2003Bonnot, 2003 6.19[2.44; 15.74]242-71%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: criticalROB mesure: unclearROB reporting: critical Total (2 studies) I2 = 49% 3.29[0.48; 22.44]1,30870.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.29[0.48; 22.44]1,308749%NATinker, 2019 Bonnot, 2003 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.29[0.48; 22.44]1,308749%NATinker, 2019 Bonnot, 2003 2 Tags Adjustment   - No  - No 0.72[0.04; 12.64]1,0667 -NATinker, 2019 1   - Yes  - Yes 6.19[2.44; 15.72]242- -NABonnot, 2003 1 BZD Coexposure   - Not specified  - Not specified 6.19[2.44; 15.72]242- -NABonnot, 2003 1   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 0.72[0.04; 12.64]1,0667 -NATinker, 2019 1 All studiesAll studies 3.29[0.48; 22.44]1,308749%NATinker, 2019 Bonnot, 2003 20.220.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.29[0.48; 22.44]1,308749%NATinker, 2019 Bonnot, 2003 20.510.01.0