Clorazepate updated on 02-10-2025

Limb reduction defects (LRD)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15653
R64633		 Bonnot, 2003 Limb Reduction Defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified 2.64 [1.13;6.16] 6/-   542/- 548 -
ref
Total 1 studies 2.64 [1.13;6.16] 548 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bonnot, 2003Bonnot, 2003 2.64[1.13; 6.16]548-0%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: criticalROB mesure: unclearROB reporting: critical0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 2.64[1.13; 6.16]548- -NABonnot, 2003 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.64[1.13; 6.16]548- -NABonnot, 2003 1 Tags Adjustment   - Yes  - Yes 2.64[1.13; 6.16]548- -NABonnot, 2003 1 BZD Coexposure   - Not specified  - Not specified 2.64[1.13; 6.16]548- -NABonnot, 2003 1 All studiesAll studies 2.64[1.13; 6.16]548- -NABonnot, 2003 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.64[1.13; 6.16]548- -NABonnot, 2003 10.510.01.0