Oxazepam (Psy and mixed indications) updated on 02-10-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15659
R64640		 Cornel - The NNL registry, 1996 Cleft lip with or without palate 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 8.17 [1.26;42.20] 3/8   274/4,006 277 8
ref
Total 1 studies 8.17 [1.41;47.28] 277 8
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cornel - The NNL registry, 1996Cornel - The NNL registry, 1996 8.17[1.26; 42.20]27780%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 8.17[1.41; 47.28]2778 -NACornel - The NNL registry, 1996 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 8.17[1.41; 47.28]2778 -NACornel - The NNL registry, 1996 1 Tags Adjustment   - No  - No 8.17[1.41; 47.28]2778 -NACornel - The NNL registry, 1996 1 BZD Coexposure   - Not specified  - Not specified 8.17[1.41; 47.28]2778 -NACornel - The NNL registry, 1996 1 All studiesAll studies 8.17[1.41; 47.28]2778 -NACornel - The NNL registry, 1996 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 8.17[1.41; 47.28]2778 -NACornel - The NNL registry, 1996 10.510.01.0