Mirtazapine updated on 07-01-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11690
R42987		 Kieler, 2015 Termination of pregnancy for Fetal anomaly during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.20 [1.10;4.50] -/-   0/- - -
ref
S12913
R48980		 Winterfeld (Controls exposed to SSRI), 2015 Therapeutic termination of pregnancy 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 2.52 [0.49;13.08]
excluded (control group) 		5/357   2/357 7 357
ref
S12914
R48987		 Winterfeld (Controls unexposed, NOS), 2015 Therapeutic termination of pregnancy 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.25 [0.33;4.71] 5/357   4/357 9 357
ref
S12911
R48962		 Djulus (Controls exposed to other antidepressants), 2006 Therapeutic abortion 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 2.06 [0.50;8.47] C
excluded (control group) 		6/104   3/104 9 104
ref
S12910
R48957		 Djulus (Controls unexposed, disease free), 2006 Therapeutic abortion 1st trimester prospective cohort unexposed, disease free Adjustment: No Matched Monotherapy: no or not specified 6.31 [0.75;53.33] C 6/104   1/104 7 104
ref
Total 3 studies 2.13 [1.17;3.87] 16 461
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kieler, 2015Kieler, 2015 2.20[1.10; 4.50]--72%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Winterfeld (Controls unexposed, NOS), 2015Winterfeld, 2015 1 1.25[0.33; 4.71]935720%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Djulus (Controls unexposed, disease free), 2006Djulus, 2006 2 6.31[0.75; 53.33]71048%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 2.13[1.17; 3.87]164610.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS; 2: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.24[0.49; 10.29]1646137%NAWinterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 2 case control studiescase control studies 2.20[1.09; 4.45]-- -NAKieler, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.13[1.17; 3.87]164610%NAKieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 3 Tags Adjustment   - No  - No 2.24[0.49; 10.29]1646137%NAWinterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 2   - Yes  - Yes 2.20[1.09; 4.45]-- -NAKieler, 2015 1 MatchedMatched 2.13[1.17; 3.87]164610%NAKieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 3 Monotherapy   - no or not specified  - no or not specified 2.24[0.49; 10.29]1646137%NAWinterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 2   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.20[1.09; 4.45]-- -NAKieler, 2015 1 All studiesAll studies 2.13[1.17; 3.87]164610%NAKieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 30.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12911, 12913

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.13[1.17; 3.87]164610%NAKieler, 2015 Winterfeld (Controls unexposed, NOS), 2015 Djulus (Controls unexposed, disease free), 2006 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.25[0.77; 6.55]164610%NAWinterfeld (Controls exposed to SSRI), 2015 Djulus (Controls exposed to other antidepressants), 2006 20.510.01.0