Mirtazapine updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12950
R49148		 Ostenfeld, 2022 Stillbirths (> 22 completed GW) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.88 [0.34;2.29] 5/1,945   28/7,780 33 1,945
ref
S12911
R48963		 Djulus (Controls exposed to other antidepressants), 2006 Stillbirth 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 3.03 [0.12;75.24] C
excluded (control group) 		1/104   0/104 1 104
ref
S12910
R48958		 Djulus (Controls unexposed, disease free), 2006 Stillbirth 1st trimester prospective cohort unexposed, disease free Adjustment: No Matched Monotherapy: no or not specified 3.03 [0.12;75.24] C 1/104   0/104 1 104
ref
Total 2 studies 0.97 [0.39;2.43] 34 2,049
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ostenfeld, 2022Ostenfeld, 2022 0.88[0.34; 2.29]331,94592%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Djulus (Controls unexposed, disease free), 2006Djulus, 2006 1 3.03[0.12; 75.24]11048%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.97[0.39; 2.43]342,0490.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.97[0.39; 2.43]342,0490%NAOstenfeld, 2022 Djulus (Controls unexposed, disease free), 2006 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.97[0.39; 2.43]342,0490%NAOstenfeld, 2022 Djulus (Controls unexposed, disease free), 2006 2 Tags Adjustment   - No  - No 3.03[0.12; 75.24]1104 -NADjulus (Controls unexposed, disease free), 2006 1   - Yes  - Yes 0.88[0.34; 2.28]331,945 -NAOstenfeld, 2022 1 MatchedMatched 3.03[0.12; 75.24]1104 -NADjulus (Controls unexposed, disease free), 2006 1 Monotherapy   - no or not specified  - no or not specified 0.97[0.39; 2.43]342,0490%NAOstenfeld, 2022 Djulus (Controls unexposed, disease free), 2006 2 All studiesAll studies 0.97[0.39; 2.43]342,0490%NAOstenfeld, 2022 Djulus (Controls unexposed, disease free), 2006 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12911

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.97[0.39; 2.43]342,0490%NAOstenfeld, 2022 Djulus (Controls unexposed, disease free), 2006 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.03[0.12; 75.24]1104 -NADjulus (Controls exposed to other antidepressants), 2006 10.510.01.0