Mirtazapine updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12950
R49147		 Ostenfeld, 2022 Spontaneous abortions (loss of pregnancy 5-22 completed gestational weeks) 1st and 2nd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.04 [0.91;1.20] 237/1,900   931/7,600 1,168 1,900
ref
S11789
R43376		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.10 [0.43;39.00] C 1/5   15/261 16 5
ref
S12911
R48961		 Djulus (Controls exposed to other antidepressants), 2006 Spontaneous abortion (NOS) 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 1.14 [0.56;2.30] C
excluded (control group) 		20/104   18/104 38 104
ref
S12910
R48956		 Djulus (Controls unexposed, disease free), 2006 Spontaneous abortion (NOS) 1st trimester prospective cohort unexposed, disease free Adjustment: No Matched Monotherapy: no or not specified 2.01 [0.91;4.45] C 20/104   11/104 31 104
ref
S11269
R41409		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 4.43 [0.48;40.72] C 1/7   9/248 10 7
ref
Total 4 studies 1.53 [0.83;2.85] 1,225 2,016
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ostenfeld, 2022Ostenfeld, 2022 1.04[0.91; 1.20]1,1681,90057%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Ozturk, 2016Ozturk, 2016 4.10[0.43; 39.00]1657%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Djulus (Controls unexposed, disease free), 2006Djulus, 2006 1 2.01[0.91; 4.45]3110430%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Yaris, 2005Yaris, 2005 4.43[0.48; 40.72]1077%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (4 studies) I2 = 46% 1.53[0.83; 2.85]1,2252,0160.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.53[0.83; 2.85]1,2252,01646%NAOstenfeld, 2022 Ozturk, 2016 Djulus (Controls unexposed, disease free), 2006 Yaris, 2005 4 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.53[0.83; 2.85]1,2252,01646%NAOstenfeld, 2022 Ozturk, 2016 Djulus (Controls unexposed, disease free), 2006 Yaris, 2005 4 Tags Adjustment   - No  - No 2.34[1.15; 4.75]571160%NAOzturk, 2016 Djulus (Controls unexposed, disease free), 2006 Yaris, 2005 3   - Yes  - Yes 1.04[0.91; 1.19]1,1681,900 -NAOstenfeld, 2022 1 MatchedMatched 2.01[0.91; 4.45]31104 -NADjulus (Controls unexposed, disease free), 2006 1 Monotherapy   - no or not specified  - no or not specified 1.53[0.83; 2.85]1,2252,01646%NAOstenfeld, 2022 Ozturk, 2016 Djulus (Controls unexposed, disease free), 2006 Yaris, 2005 4 All studiesAll studies 1.53[0.83; 2.85]1,2252,01646%NAOstenfeld, 2022 Ozturk, 2016 Djulus (Controls unexposed, disease free), 2006 Yaris, 2005 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.73.11.3790.000Ostenfeld, 2022Ozturk, 2016Djulus (Controls unexposed, disease free), 2006Yaris, 2005

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded 12911

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.53[0.83; 2.85]1,2252,01646%NAOstenfeld, 2022 Ozturk, 2016 Djulus (Controls unexposed, disease free), 2006 Yaris, 2005 4 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.14[0.56; 2.30]38104 -NADjulus (Controls exposed to other antidepressants), 2006 10.510.01.0