Mirtazapine updated on 07-01-2025

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12913
R48981		 Winterfeld (Controls exposed to SSRI), 2015 Miscarriage or stillbirth 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 1.01 [0.63;1.61]
excluded (control group) 		39/323   41/342 80 323
ref
S12914
R48988		 Winterfeld (Controls unexposed, NOS), 2015 Miscarriage or stillbirth 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.34 [0.81;2.20] 39/323   31/333 70 323
ref
Total 1 studies 1.34 [0.81;2.21] 70 323
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Winterfeld (Controls unexposed, NOS), 2015Winterfeld, 2015 1 1.34[0.81; 2.20]703230%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 1 Tags Adjustment   - No  - No 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 1 MatchedMatched 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 1 Monotherapy   - no or not specified  - no or not specified 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 1 All studiesAll studies 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12913

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.34[0.81; 2.21]70323 -NAWinterfeld (Controls unexposed, NOS), 2015 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.01[0.63; 1.61]80323 -NAWinterfeld (Controls exposed to SSRI), 2015 10.510.01.0