Diazepam updated on 02-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15613
R64442		 Meng b, 2023 Miscarriage (between 8th-19th weeks of gestation; ICD-9 codes 631, 632, 634, 637, 640; ICD-10 codes 631, 632, 634, 637, 640) during pregnancy (anytime or not specified) other unexposed, sick Adjustment: Yes BZD Coexposure: Not specified Matched 1.69 [1.31;2.19] -/-   0/- - -
ref
S15417
R63488		 Sheehy, 2019 Spontaneous abortion (6th to 19th completed week of gestation) - ICD-9 diagnosis code 634 or ICD-10 diagnosis code O03 early pregnancy nested case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Not specified Matched 3.43 [1.42;8.32] 12/27   27,137/161,427 27,149 27
ref
Total 2 studies 2.11 [1.11;4.02] 27,149 27
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Meng b, 2023Meng b, 2023 1.69[1.31; 2.19]--69%ROB confusion: lowROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Sheehy, 2019Sheehy, 2019 3.43[1.42; 8.32]27,1492731%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 56% 2.11[1.11; 4.02]27,149270.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.69[1.31; 2.19]-- -NAMeng b, 2023 1 case control studiescase control studies 3.43[1.42; 8.30]27,14927 -NASheehy, 2019 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.43[1.42; 8.30]27,14927 -NASheehy, 2019 1 unexposed, sickunexposed, sick 1.69[1.31; 2.19]-- -NAMeng b, 2023 1 Tags Adjustment   - Yes  - Yes 2.11[1.11; 4.02]27,1492756%NAMeng b, 2023 Sheehy, 2019 2 BZD Coexposure   - Not specified  - Not specified 2.11[1.11; 4.02]27,1492756%NAMeng b, 2023 Sheehy, 2019 2 MatchedMatched 2.11[1.11; 4.02]27,1492756%NAMeng b, 2023 Sheehy, 2019 2 All studiesAll studies 2.11[1.11; 4.02]27,1492756%NAMeng b, 2023 Sheehy, 2019 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.43[1.42; 8.30]27,14927 -NASheehy, 2019 1 unexposed, sick controlsunexposed, sick controls 1.69[1.31; 2.19]-- -NAMeng b, 2023 10.510.01.0