| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S17689 R74656 |
Laspro, 2024 | Oral clefts (ICD 10 codes Q35 or Q36 or Q37) | during pregnancy (anytime or not specified) excluded | nested case control | unexposed (general population or NOS) | Adjustment: No BZD Coexposure: Not specified |
1.30 [1.04;1.64] excluded (exposition period) |
73/- 12,025/- | 12,098 | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S15649 R64582 |
Ban (Other indications) (Controls unexposed, disease free), 2014 | Oro-facial cleft | 1st trimester | retrospective cohort (claims database) | unexposed, disease free excluded | Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) |
0.33 [0.02;5.23] C excluded (control group) |
0/1,159 464/351,785 | 464 | 1,159 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S15650 R64598 |
Ban (Other indications) (Controls unexposed, sick), 2014 | Oro-facial cleft | 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) | 0.23 [0.01;3.80] C | 0/1,159 35/19,193 | 35 | 1,159 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S15645 R64568 |
Shiono, 1984 | Oral clefts | 1st trimester | cohort | unexposed (general population or NOS) | Adjustment: No BZD Coexposure: Not specified | 1.22 [0.17;8.95] | 1/854 31/32,395 | 32 | 854 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S15648 R64572 |
Aarskog, 1975 | Oral clefts | 1st trimester | case control | unexposed (general population or NOS) | Adjustment: No BZD Coexposure: Not specified | 6.02 [1.73;20.98] C | 7/11 104/462 | 111 | 11 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 3 studies | 1.65 [0.28;9.92] | 178 | 2,024 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Other indications) (Controls unexposed, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 15649