Diazepam updated on 02-10-2025

Ear, face and neck anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15649
R64588		 Ban (Other indications) (Controls unexposed, disease free), 2014 Ear, face and neck malformations 1st trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 1.64 [0.10;26.45] C
excluded (control group) 		0/1,159   92/351,785 92 1,159
ref
S15650
R64604		 Ban (Other indications) (Controls unexposed, sick), 2014 Ear, face and neck malformations 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: No BZD Coexposure: No (among psychiatric (ATD and/or psychotropics) medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 1.10 [0.06;19.34] C 0/1,159   7/19,193 7 1,159
ref
Total 1 studies 1.10 [0.06;19.34] 7 1,159
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Other indications) (Controls unexposed, sick), 2014Ban, 2014 1 1.10[0.06; 19.34]71,1590%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: moderateROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Other indications) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 1 Tags Adjustment   - No  - No 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 1 BZD Coexposure   - No (among psychiatric (ATD and/or p ...  - No (among psychiatric (ATD and/or psychotropics) medications) 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 1 All studiesAll studies 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15649

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.64[0.10; 26.45]921,159 -NABan (Other indications) (Controls unexposed, disease free), 2014 1 unexposed, sick controlsunexposed, sick controls 1.10[0.06; 19.34]71,159 -NABan (Other indications) (Controls unexposed, sick), 2014 10.510.01.0