Diazepam updated on 02-10-2025

Gastroschisis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15602
R64337		 Tinker, 2019 Gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 0.46 [0.06;3.43] C 1/19   1,399/12,914 1,400 19
ref
S15661
R64663		 Czeizel, 2003 Exomphalos /gastroschisis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched 0.90 [0.30;2.80] -/-   238/- - -
ref
Total 2 studies 0.77 [0.29;2.04] 1,400 19
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 0.46[0.06; 3.43]1,4001924%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Czeizel, 2003Czeizel, 2003 0.90[0.30; 2.80]--76%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 0.77[0.29; 2.04]1,400190.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.77[0.29; 2.04]1,400190%NATinker, 2019 Czeizel, 2003 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.77[0.29; 2.04]1,400190%NATinker, 2019 Czeizel, 2003 2 Tags Adjustment   - No  - No 0.46[0.06; 3.43]1,40019 -NATinker, 2019 1   - Yes  - Yes 0.90[0.29; 2.75]-- -NACzeizel, 2003 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 0.77[0.29; 2.04]1,400190%NATinker, 2019 Czeizel, 2003 2 MatchedMatched 0.90[0.29; 2.75]-- -NACzeizel, 2003 1 All studiesAll studies 0.77[0.29; 2.04]1,400190%NATinker, 2019 Czeizel, 2003 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.77[0.29; 2.04]1,629190%NATinker, 2019 Czeizel, 2003 20.510.01.0