Diazepam updated on 02-10-2025

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15602
R64329		 Tinker, 2019 Esophageal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 0.85 [0.11;6.38] C 1/19   752/12,267 753 19
ref
S15661
R64654		 Czeizel, 2003 Esophageal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched 2.10 [0.50;8.50] -/-   223/- - -
ref
S15665
R64685		 Safra, 1975 Oesophageal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 2.12 [0.25;18.05] C 1/16   8/262 9 16
ref
Total 3 studies 1.67 [0.60;4.63] 762 35
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 0.85[0.11; 6.38]7531926%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Czeizel, 2003Czeizel, 2003 2.10[0.50; 8.50]--52%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Safra, 1975Safra, 1975 2.12[0.25; 18.05]91623%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 0% 1.67[0.60; 4.63]762350.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.67[0.60; 4.63]762350%NATinker, 2019 Czeizel, 2003 Safra, 1975 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.67[0.60; 4.63]762350%NATinker, 2019 Czeizel, 2003 Safra, 1975 3 Tags Adjustment   - No  - No 1.30[0.30; 5.66]762350%NATinker, 2019 Safra, 1975 2   - Yes  - Yes 2.10[0.51; 8.66]-- -NACzeizel, 2003 1 BZD Coexposure   - Not specified  - Not specified 2.12[0.25; 18.05]916 -NASafra, 1975 1   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.56[0.49; 4.96]753190%NATinker, 2019 Czeizel, 2003 2 MatchedMatched 2.10[0.51; 8.66]-- -NACzeizel, 2003 1 All studiesAll studies 1.67[0.60; 4.63]762350%NATinker, 2019 Czeizel, 2003 Safra, 1975 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.67[0.60; 4.63]976350%NATinker, 2019 Czeizel, 2003 Safra, 1975 30.510.01.0