Diazepam updated on 02-10-2025

Diaphragmatic hernia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15602
R64335		 Tinker, 2019 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 1.48 [0.34;6.39] C 2/20   865/12,380 867 20
ref
S15665
R64689		 Safra, 1975 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 0.80 [0.04;14.39] C 0/16   10/262 10 16
ref
Total 2 studies 1.31 [0.35;4.81] 877 36
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 1.48[0.34; 6.39]8672080%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Safra, 1975Safra, 1975 0.80[0.04; 14.39]101620%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 0% 1.31[0.35; 4.81]877360.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.31[0.35; 4.81]877360%NATinker, 2019 Safra, 1975 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.31[0.35; 4.81]877360%NATinker, 2019 Safra, 1975 2 Tags Adjustment   - No  - No 1.31[0.35; 4.81]877360%NATinker, 2019 Safra, 1975 2 BZD Coexposure   - Not specified  - Not specified 0.80[0.04; 14.39]1016 -NASafra, 1975 1   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.48[0.34; 6.39]86720 -NATinker, 2019 1 All studiesAll studies 1.31[0.35; 4.81]877360%NATinker, 2019 Safra, 1975 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.31[0.35; 4.81]877360%NATinker, 2019 Safra, 1975 20.510.01.0