Diazepam updated on 02-10-2025

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15602
R64330		 Tinker, 2019 Anorectal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 0.29 [0.02;4.85] C 0/18   1,066/12,581 1,066 18
ref
S15661
R64655		 Czeizel, 2003 Rectal/anal atresia/stenosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched 5.20 [1.40;19.70] -/-   229/- - -
ref
S15665
R64687		 Safra, 1975 Rectal and anal atresia 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 0.52 [0.03;9.02] C 0/16   15/262 15 16
ref
Total 3 studies 1.30 [0.18;9.45] 1,081 34
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 0.29[0.02; 4.85]1,0661827%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Czeizel, 2003Czeizel, 2003 5.20[1.40; 19.70]--47%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Safra, 1975Safra, 1975 0.52[0.03; 9.02]151626%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 56% 1.30[0.18; 9.45]1,081340.220.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.30[0.18; 9.45]1,0813456%NATinker, 2019 Czeizel, 2003 Safra, 1975 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.30[0.18; 9.45]1,0813456%NATinker, 2019 Czeizel, 2003 Safra, 1975 3 Tags Adjustment   - No  - No 0.39[0.05; 2.87]1,081340%NATinker, 2019 Safra, 1975 2   - Yes  - Yes 5.20[1.39; 19.51]-- -NACzeizel, 2003 1 BZD Coexposure   - Not specified  - Not specified 0.52[0.03; 9.02]1516 -NASafra, 1975 1   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 1.63[0.10; 25.93]1,0661870%NATinker, 2019 Czeizel, 2003 2 MatchedMatched 5.20[1.39; 19.51]-- -NACzeizel, 2003 1 All studiesAll studies 1.30[0.18; 9.45]1,0813456%NATinker, 2019 Czeizel, 2003 Safra, 1975 30.120.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.30[0.18; 9.45]1,3013456%NATinker, 2019 Czeizel, 2003 Safra, 1975 30.510.01.0