Diazepam updated on 02-10-2025

Ventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15602
R64310		 Tinker, 2019 Perimembranous ventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) 0.39 [0.05;2.91] C 1/19   1,647/13,162 1,648 19
ref
S15666
R64691		 Tikkanen, 1991 Ventricular septal defect 1st trimester nested case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified 1.26 [0.27;6.01] C 2/10   148/896 150 10
ref
Total 2 studies 0.81 [0.24;2.79] 1,798 29
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Tinker, 2019Tinker, 2019 0.39[0.05; 2.91]1,6481937%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Tikkanen, 1991Tikkanen, 1991 1.26[0.27; 6.01]1501063%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: critical Total (2 studies) I2 = 0% 0.81[0.24; 2.79]1,798290.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.81[0.24; 2.79]1,798290%NATinker, 2019 Tikkanen, 1991 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.81[0.24; 2.79]1,798290%NATinker, 2019 Tikkanen, 1991 2 Tags Adjustment   - No  - No 0.81[0.24; 2.79]1,798290%NATinker, 2019 Tikkanen, 1991 2 BZD Coexposure   - Not specified  - Not specified 1.26[0.27; 6.01]15010 -NATikkanen, 1991 1   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 0.39[0.05; 2.91]1,64819 -NATinker, 2019 1 All studiesAll studies 0.81[0.24; 2.79]1,798290%NATinker, 2019 Tikkanen, 1991 20.15.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.81[0.24; 2.79]1,798290%NATinker, 2019 Tikkanen, 1991 20.510.01.0