Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15674
R64716		 Coste (Indications other than epilepsy), 2020 Neonatal condition during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No BZD Coexposure: No (among antiseizure medications) 1.26 [1.08;1.46] C 197/1,246   222,201/1,710,441 222,398 1,246
ref
Total 1 studies 1.26 [1.08;1.46] 222,398 1,246
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste (Indications other than epilepsy), 2020Coste, 2020 1 1.26[1.08; 1.46]222,3981,2460%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Indications other than epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.26[1.08; 1.46]222,3981,246 -NACoste (Indications other than epilepsy), 2020 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.26[1.08; 1.46]222,3981,246 -NACoste (Indications other than epilepsy), 2020 1 Tags Adjustment   - No  - No 1.26[1.08; 1.46]222,3981,246 -NACoste (Indications other than epilepsy), 2020 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 1.26[1.08; 1.46]222,3981,246 -NACoste (Indications other than epilepsy), 2020 1 All studiesAll studies 1.26[1.08; 1.46]222,3981,246 -NACoste (Indications other than epilepsy), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.26[1.08; 1.46]222,3981,246 -NACoste (Indications other than epilepsy), 2020 10.510.01.0