Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Small for gestational age (weight)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17718 R74732	Christensen (Indications other than epilepsy), 2024	Small for gestational age (a z-score for birth weight ≤10th percentile for gestational week, sex, and country (including newborns with congenital malformations))	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: No (among antiseizure medications) Indication BZD: Psychiatric diseases (depression, anxiety, ...)	1.22 [1.02;1.45]	164/1,019 443,851/4,445,621	444,015	1,019		ref
S15674 R64715	Coste (Indications other than epilepsy), 2020	Small for gestational age (weight)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	1.35 [1.14;1.59] ^C	159/1,246 167,376/1,710,441	167,535	1,246		ref
					Total	2 studies	1.29 [1.14;1.45]		611,550	2,265
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications other than epilepsy; 2: Indications other than epilepsy;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)