Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15416 R63487	Sheehy (Indications NOS), 2019	Spontaneous abortion (6th to 19th completed week of gestation) - ICD-9 diagnosis code 634 or ICD-10 diagnosis code O03	early pregnancy	nested case control	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Not specified Matched	1.77 [1.31;2.41]	82/220 27,067/161,234	27,149	220		ref
S15669 R64694	Bech (Indications other than epilepsy), 2014	Spontaneous abortions (ICD codes O02.0-O03.9)	1st and 2nd trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Not specified	1.91 [1.54;2.37]	60/219 108,273/812,862	108,333	219		ref
					Total	2 studies	1.86 [1.56;2.22]		135,482	439
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications NOS; 2: Indications other than epilepsy;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded