Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Cognitive developmental disorders/delay (< 3 years old)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15677
R64737		 Oberlander (Controls unexposed, disease free) (Indications other than epilepsy), 2004 Mental developmental index from Bayley scales of infant development - At 8 months during pregnancy (anytime or not specified) prospective cohort unexposed, disease free excluded Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Co-administration extrapolated (cont. endpoint) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 2.14 [0.69;6.63]
excluded (control group) 		-/18   -/23 - 18
ref
S15678
R64743		 Oberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 Mental developmental index from Bayley scales of infant development - At 8 months during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Co-administration extrapolated (cont. endpoint) Indication BZD: Psychiatric diseases (depression, anxiety, ...) 2.96 [0.99;8.90] -/18   -/28 - 18
ref
Total 1 studies 2.96 [0.99;8.88] 0 18
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Oberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004Oberlander, 2004 1 2.96[0.99; 8.90]-180%ROB confusion: criticalROB selection: lowROB classification: unclearROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick) (Indications other than epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 Tags Adjustment   - No  - No 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 BZD Coexposure   - Yes (with psychiatric (ATD and/or p ...  - Yes (with psychiatric (ATD and/or psychotropics) medications) 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 Co-administrationCo-administration 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 Indication BZD   - Psychiatric diseases (depression, a ...  - Psychiatric diseases (depression, anxiety, ...) 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 1 All studiesAll studies 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15677

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.14[0.69; 6.63]-18 -NAOberlander (Controls unexposed, disease free) (Indications other than epilepsy), 2004 1 unexposed, sick controlsunexposed, sick controls 2.96[0.99; 8.88]-18 -NAOberlander (Controls unexposed, sick) (Indications other than epilepsy), 2004 10.510.01.0