Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

ASD (Autism spectrum disorder): Diagnosis/Risk

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15671 R64701	Bjørk (Mixed indications), 2022	Diagnosis autism spectrum disorder (ASD): childhood autism (F84.0), atypical autism (F84.1), and Asperger syndrome (F84.5) - Median follow up clonazepam 9.5 (5.5-13.9) years old	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: No (among antiseizure medications)	1.43 [0.96;2.12]	25/1,182 38,437/4,463,879	38,462	1,182		ref
S15674 R64726	Coste (Indications other than epilepsy), 2020	Diagnosis Pervasive developmental disorders (F84) - Mean age follow-up 4.4 years old	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: No (among antiseizure medications)	1.10 [0.50;2.10]	8/1,246 4,280/1,710,441	4,288	1,246		ref
					Total	2 studies	1.34 [0.95;1.90]		42,750	2,428
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Mixed indications; 2: Indications other than epilepsy;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)