Clonazepam (Psy and Mixed indications) updated on 02-10-2025

ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15673
R64708		 Christensen (Indications NOS), 2019 ADHD Diagnoses with follow up from birth during pregnancy (anytime or not specified) population based cohort propective unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: No (among antiseizure medications) 1.43 [0.95;2.16] 25/314   27,832/883,311 27,857 314
ref
Total 1 studies 1.43 [0.95;2.16] 27,857 314
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Indications NOS), 2019Christensen, 2019 1 1.43[0.95; 2.16]27,8573140%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Indications NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.43[0.95; 2.16]27,857314 -NAChristensen (Indications NOS), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.43[0.95; 2.16]27,857314 -NAChristensen (Indications NOS), 2019 1 Tags Adjustment   - Yes  - Yes 1.43[0.95; 2.16]27,857314 -NAChristensen (Indications NOS), 2019 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 1.43[0.95; 2.16]27,857314 -NAChristensen (Indications NOS), 2019 1 All studiesAll studies 1.43[0.95; 2.16]27,857314 -NAChristensen (Indications NOS), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.43[0.95; 2.16]27,857314 -NAChristensen (Indications NOS), 2019 10.510.01.0