Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Learning disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8330
R26385		 Elkjaer (Indications, NOS), 2018 Danish at 6th grade (mean age 12.9 years old) during pregnancy (anytime or not specified) population based cohort propective unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: No (among antiseizure medications) extrapolated (cont. endpoint) 1.14 [1.00;1.29] -/101   -/242,148 - 101
ref
Total 1 studies 1.14 [1.00;1.29] 0 101
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Elkjaer (Indications, NOS), 2018Elkjaer, 2018 1 1.14[1.00; 1.29]-1010%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Indications, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 1 Tags Adjustment   - Yes  - Yes 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 1 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 1 All studiesAll studies 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.14[1.00; 1.29]-101 -NAElkjaer (Indications, NOS), 2018 10.510.01.0