Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Hypoplastic left heart (HLH/HLHS)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15651
R64613		 Blotière (Indications other than epilepsy), 2019 Hypoplastic left heart syndrome 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No BZD Coexposure: No (among antiseizure medications) 4.42 [0.28;70.98] C 0/980   216/1,875,733 216 980
ref
Total 1 studies 4.42 [0.28;70.98] 216 980
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Blotière (Indications other than epilepsy), 2019Blotière, 2019 1 4.42[0.28; 70.98]2169800%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Indications other than epilepsy;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.42[0.28; 70.98]216980 -NABlotière (Indications other than epilepsy), 2019 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.42[0.28; 70.98]216980 -NABlotière (Indications other than epilepsy), 2019 1 Tags Adjustment   - No  - No 4.42[0.28; 70.98]216980 -NABlotière (Indications other than epilepsy), 2019 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 4.42[0.28; 70.98]216980 -NABlotière (Indications other than epilepsy), 2019 1 All studiesAll studies 4.42[0.28; 70.98]216980 -NABlotière (Indications other than epilepsy), 2019 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.42[0.28; 70.98]216980 -NABlotière (Indications other than epilepsy), 2019 10.510.01.0