Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Spina bifida

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15651 R64607	Blotière (Indications other than epilepsy), 2019	Spina bifida	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	1.55 [0.10;24.87] ^C	0/980 616/1,875,733	616	980		ref
S15601 R64289	Tinker (Mixed indications), 2019	Spina bifida	1st trimester	case control	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.30 [0.40;4.40]	3/24 1,238/12,750	1,241	24		ref
					Total	2 studies	1.34 [0.44;4.02]		1,857	1,004
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications other than epilepsy; 2: Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded