Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Oesophageal atresia with or without tracheo-oesophageal fistula

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15651 R64620	Blotière (Indications other than epilepsy), 2019	Atresia of esophagus	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	4.90 [0.10;27.40]	1/980 392/1,875,733	393	980		ref
S15601 R64296	Tinker (Mixed indications), 2019	Esophageal atresia/stenosis	1st trimester	case control	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	0.73 [0.10;5.43] ^C	1/22 752/12,264	753	22		ref
S17865 R75464	Eros (Indications NOS), 2002	Esophageal atresia/stenosis	during pregnancy (anytime or not specified) excluded	case control	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched	no data excluded (exposition period)	0/- -/-	-	-		ref
					Total	2 studies	1.45 [0.24;8.75]		1,146	1,002
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications other than epilepsy; 2: Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded