Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Ano-rectal atresia and stenosis

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15651 R64621	Blotière (Indications other than epilepsy), 2019	Anorectal atresia	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	1.76 [0.11;28.16] ^C	0/980 544/1,875,733	544	980		ref
S15601 R64297	Tinker (Mixed indications), 2019	Anorectal atresia/stenosis	1st trimester	case control	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	1.03 [0.24;4.40] ^C	2/23 1,064/12,576	1,066	23		ref
S17865 R75465	Eros (Indications NOS), 2002	Rectal–anal atresia/stenosis	during pregnancy (anytime or not specified) excluded	case control	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched	no data excluded (exposition period)	0/- -/-	-	-		ref
					Total	2 studies	1.16 [0.32;4.18]		1,610	1,003
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications other than epilepsy; 2: Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded