Clonazepam (Psy and Mixed indications) - Medication and Pregnancy KB

Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Hypospadias

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15651 R64622	Blotière (Indications other than epilepsy), 2019	Hypospadias	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: No (among antiseizure medications)	0.90 [0.10;3.30]	2/- 3,371/-	3,373	-		ref
S15601 R64298	Tinker (Mixed indications), 2019	Hypospadias	1st trimester	case control	unexposed (general population or NOS)	Adjustment: Yes BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications)	0.80 [0.20;2.70]	5/- 2,535/-	2,540	-		ref
S17865 R75477	Eros (Indications NOS), 2002	Hypospadias	during pregnancy (anytime or not specified) excluded	case control	unexposed (general population or NOS)	Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched	1.00 [0.10;15.00] excluded (exposition period)	1/- -/-	-	-		ref
					Total	2 studies	0.83 [0.29;2.37]		5,913	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Indications other than epilepsy; 2: Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)