Clonazepam (Psy and Mixed indications) updated on 02-10-2025

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15672
R64704		 Christensen (Indications NOS), 2013 Childhood autism (mean age almost 9 years old) during pregnancy (anytime or not specified) population based cohort propective unexposed (general population or NOS) Adjustment: Yes BZD Coexposure: No (among antiseizure medications) 0.90 [0.10;6.70] 2/269   2,063/655,233 2,065 269
ref
Total 1 studies 0.90 [0.11;7.37] 2,065 269
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Indications NOS), 2013Christensen, 2013 1 0.90[0.10; 6.70]2,0652690%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Indications NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.90[0.11; 7.37]2,065269 -NAChristensen (Indications NOS), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.90[0.11; 7.37]2,065269 -NAChristensen (Indications NOS), 2013 1 Tags Adjustment   - Yes  - Yes 0.90[0.11; 7.37]2,065269 -NAChristensen (Indications NOS), 2013 1 BZD Coexposure   - No (among antiseizure medications)  - No (among antiseizure medications) 0.90[0.11; 7.37]2,065269 -NAChristensen (Indications NOS), 2013 1 All studiesAll studies 0.90[0.11; 7.37]2,065269 -NAChristensen (Indications NOS), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.11; 7.37]2,065269 -NAChristensen (Indications NOS), 2013 10.510.01.0